I've been giving the new ZBrush features a good workout and I have some observations that might be useful for others here. I'll add more if I find any, and others are welcome to post their findings here too.
Okay, here we go:
1. For those like me who get annoyed when opening a palette and seeing the last one opened closing up (meaning only one palette at a time can be open), I previously used a workaround of holding Shift when clicking a palette so that each one clicked stays open. Now there is an option in ZBrush 2018 (which I don't think was there in 4R8) to do just that without holding Shift. Just go to Preferences>Interface>Palettes, then untick "One open subpalette" and you are set. Oh, and click on "Store Config" so ZBrush remembers this every time you open the program.
2. Sculptris Pro is super, really super in my opinion. But not all the brushes work it, particularly the Move brushes (Move, Move Topological, Move Elastic) which is really annoying as the Move brush has to be one of the most used. Now there is a new Snakehook 2 brush, which essentially works like a Move brush with some nice extra functions. For instance, you can smooth away geometry almost like sing an eraser!
3. The main and secondary colour swatches are in the wrong spots, secondary swatch on the left and main one to the right of it. It was like this in 4R8 and is very annoying, 4R7 had the Main swatch on the left (like in Photoshop) which is I think the natural way to do it and I really don't know why Pixologic didn't leave it alone. Fortunately we can swap the swatches around by going to Preferences>Enable Customize and then holding Ctrl+Alt and dragging each swatch to its traditional position. Then Store Config and Save UI so they stay there next time you open ZBrush.
4. The Polyframe icon has a line fill On/Off setting, which basically give us wires view without the polygroup colours. I don't remember if this option was in 4R8, but I think it is new for 2018.
5. Sometimes when I click the Maximize icon to maximize ZBrush, instead it opens another instance of the interface, which appears to be a bug. Closing the dupe interface shuts the whole program down, so instead of closing it we need to Maximize it instead and it goes back to one instance open.
6. Beside the ZAdd uttion, there is a ZCut one. It took me a while to find out in the Pixologic Docs that this only works in Draw mode, not in Edit.
7. Anyone with ZBrush 4R8 doesn't need to uninstall it. We can have 4R8 and 2018 installed, but only one open at a time. Also, ZBrush 2018 native format files won't open in 4R8.
That's it so far from me!